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In line with the current interest in protein kinases inhibitors as potential drugs against a variety of diseases, the possibility that protein kinases may represent targets for novel anti-parasitic agents is being explored.
These markers may represent targets for future therapeutic intervention as they include genes such as Gata4 that are exclusively expressed during lung development.
High-level expression of hsa-miR-30b and hsa-miR-30d was closely correlated with their copy number status (Figures 3A & B), suggesting these may represent targets.
The cohort of stem-related genes that also appear to be deregulated in prostate tumors (Table S15) may represent targets for novel therapeutic strategies for treating prostatic diseases.
Thus, the signaling pathways activated by CXCL12 and its receptor, CXCR4, were investigated as components of these pathways and may represent targets that if inhibited, could render resistant CLL cells more susceptible to chemotherapy.
These may represent targets for future functional studies.
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For some miRNAs that exist within 'families', this may be explained by intrafamilial redundancy however for others this may represent target sharing by several distinct miRNAs.
Afadin functions downstream of angiogenic signals translated by VEGF and S1P in ECs and also may represent target for modulating AG.
Therefore, these resistance proteins may also represent targets for antibiotic production improvement strategies [ 12, 13].
Both AMOT-p80 and miR-146a, identified here as novel HOXD10 targets, may represent therapeutic targets at particular tumour-promoting stages.
Some of the identified β-catenin/TCF directed or indirected target genes may represent excellent targets to limit tumor growth.
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