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We include a background rate of disease which may represent sporadic cases, or the effect of genetic background.
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It could be hypothesised that this case may represent a sporadic VHL mutation.
Thus, our group of controls is more likely to represent sporadic breast cancers than those identified through a genetic testing program, many of whom may have inherited breast cancers, although not through a germline BRCA1 or 2 mutation.
With few exceptions, all the current human H7N9 and coronavirus cases represent sporadic animal-to-human transmission.
These unusual cases of BSE putatively represent sporadic cases, like most cases of CJD in humans [12].
It is likely that a proportion of these cases represent sporadic colorectal carcinomas unrelated to HDGC.
Our study clearly demonstrates that tubulin mutations may represent a significant cause of sporadic microlissencephaly with corpus callosum agenesis.
The origin of H-type and L-type BSE cases is unknown, but they may represent spontaneous or so-called sporadic forms of TSE, reminiscent of most cases of Creutzfeldt-Jakob disease in humans.
The CDH1 163+37235G>A polymorphism may represent a novel susceptibility variant for sporadic DGC if confirmed in other populations.
Furthermore, many studies of desmoids are confounded by inclusion of both FAP-associated and sporadic disease, which may represent two biologically distinct entities.
Furthermore, the two late-onset BIBD cases exhibit clinical and pathologic features that are distinct from most reported cases of BIBD suggesting that late-onset sporadic ALS with BIBD neuropathology may represent an extreme example on one end of the diverse spectrum of sporadic FUS inclusion diseases.
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