Four bmr loci in Z. mays, bm1, bm2, bm3 and bm4, represent spontaneous mutants that were first isolated almost a century ago; an additional locus, bm5, was identified later [ 40].
The 496 SNPs that were not detected in the inoculum (Table S3) probably represent spontaneous mutations produced shortly after the bottleneck, while some may be low-frequency parental variants not detected by ultra-deep sequencing.
Downward deflections represent spontaneous IPSCs.
This implies that the LNA1-AS-induced cell detachment may represent nonspecific or spontaneous cell death as seen in vehicle and untreated samples.
Thus the polyploidy cells observed may represent a response to spontaneous DNA damage, replication fork collapse due to stalling in repetitive regions of the genome, defects in post-replication events such as decatenation leading to SAC activation and mitotic slippage, or a failure in cytokinesis following normal mitosis.
Such signals may represent therapeutic targets to support spontaneous repair or complement existing biological joint resurfacing techniques.
Of course, there are numerous other studies that suggest that ET tube resistance may represent a significant impediment to spontaneous breathing.
Because of the limited source of primary human BC tissues due to early diagnosis and multiple histopathological analysis required during and after surgery, and the lack of in vivo preclinical models that accurately reflect patients' tumor biology, the study of pet spontaneous tumors may represent an innovative approach.
This suggests that changes of mind induced by outside events may represent a slightly different process from spontaneous vacillation.
These elevations, which occur with several drugs, may represent true mild liver injury with spontaneous resolution, or "adaptation," but they do not represent clinically important liver injury.
