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These mitochondrial mutations may be linked to a field effect [ 24], which suggests that mutations in the mitochondrial genome may represent sensitive markers for neoplastic transformation [ 25].
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Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST.
Furthermore, the delayed component of the biphasic response was strongly associated with the noxious heat stimuli, suggesting that this may represent a sensitive fMRI link of pain processing.
Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations.
These hypermutable CRCs may represent a sensitive system for generation, selection and detection of mutation hotspots.
Plasma bile acids may represent a sensitive non-invasive marker of liver dysfunction in HIV patients on ART.
Each stage may represent a sensitive developmental window during which exposure to environmental factors modifies BC risk.
The evidence suggesting that gait speed may represent a sensitive marker for cognitive decline in the elderly requires support from diverse racial groups.
Our findings, together with those of previous studies [ 77, 83], suggest that plasma bile acids may represent a sensitive non-invasive marker of liver dysfunction in HIV patients.
There are several possible explanations that could account for this observation – it may represent redox sensitive Cys326-OGG1 complex formation at sites of protein synthesis in the cell.
Alternatively, impaired kidney function may represent a sensitive marker of the adverse biologic pathways activated by insulin resistance without lying in the direct causal pathway.
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