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This may represent reporting bias in that patients are more likely to self-report adverse effects of a medication than clinicians are to record them [26] or it may represent an excuse for stopping the medication.
IR systems may represent reporting culture and often in themselves are not granular enough to derive better safety outcomes because of lack of how each was followed up.
Although this study represents a convenience sample because of chart availability and may represent reporting bias, the case-patients reported had high case-fatality and disability rates at last known follow-up evaluation at 60 days.
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In the Magpie Trial follow up study overall, only one third of women did not report any health problems, and even this may represent under reporting [ 10].
This change may represent better reporting as well as states turning more to other sources of funds during the recession.
Despite negative stains and cultures, the identification of DNA from M. neoaurum suggests that this case may represent the first reported CNS infection from this organism, as well as the first documented fatality.
Hypothesis 2 proposed that reporting perceived family burden may represent an increased likelihood of reporting having had a mental health difficulty within the last 12 months.
To our best knowledge, this may represent the first report that a functional ligand was successfully anchored to the surface of pure nanodrug by using a cage-like stabilizer, showing unique biological functions in gastrointestinal tract and having an important significance in oral drug delivery.
As such, the chuviruses may represent the first report of autonomously replicating circular RNA viruses, which opens up an important line of future research.
In addition, IRRs were defined in this analysis as events that occurred during or within 24 hours of an infusion, which does not capture those that may have occurred after one week, for example; therefore, the data recorded in this registry may represent an under-reporting of the level of IRRs.
Likewise, we estimate that every hospitalized case of pandemic (H1N1) 2009 that was reported may represent a median of 2.7 total hospitalized persons (90% range 1.9 4.3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com