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These findings may represent renal dysfunction due to multiorgan damage caused by more severe infection and also hyponatremia that may be due to fluid sequestration in more severe soft tissue infections.
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These increased urinary levels may represent local renal TMAO synthesis or renal excretion of circulating TMAO.
The proliferation and migration of LRCs was also observed during normal homeostasis, and their number decreased with age, suggesting they may represent a renal stem cell pool responding to IRI [106].
The wedge nephrogram may represent focal renal ischemia.
Although imaging can be used to diagnose most of them, some are incorrectly believed to represent renal cell carcinoma and unnecessary surgery may be performed.
Nevertheless, the new association among FMF, nephrotic syndrome, fibrillary glomerulopathy, and an M680I heterozygous genotype may represent a novel renal complication of FMF.
The four markers that correlated with the extent of renal injury may represent potential new biomarkers for renal injury and need further identification.
Although not associated with death, sARF in patients with co-morbid renal disease may represent a cohort less likely to recover renal function and subsequently require chronic RRT as suggested by our study.
This may represent either an accelerated renal maturation or early compensatory kidney hypertrophy in the SGA infants.
This would support recent suggestions that proteinuria and reduced glomerular filtration rate may represent different types of renal dysfunction, rather than being a measure of increased severity [ 5].
A more complete understanding of preclinical factors that may increase future renal risk is of particular importance during the transition from adolescence to early adulthood, which may represent a crucial period when renal injury is initiated (10).
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