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Our work indicates that CX3CL1 and GM-CSF may represent putative biomarkers of inflammation associated with atherosclerosis, such as C-reactive protein, but are mechanistically tied to atherosclerosis based on the well established findings in animal models of atherosclerosis.
We identified potential −35 and −10 sequences and a dyad symmetrical sequence lying upstream of pMR68 merR and upstream of merT1, respectively; these sequences may represent putative promoters of the mer operon of cluster 1 in pMR68.
Increased Fragilis expression was sustained at later stages, suggesting that these cells are not homogenous and may represent putative PGCs at various stages of specification/differentiation.
The latter may represent putative horizontal gene transfer events.
Unannotated transcripts may represent putative novel M. angustirostris-specific genes and splice isoforms.
PER2 may represent putative clinical biomarkers and possible targets of individualized therapy in PDAC.
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According to the multifocal nature of KS, we recently demonstrated that circulating endothelial progenitor cells cultured from the peripheral blood of cKS patients are infected by HHV-8, support viral productive replication and may therefore represent putative precursors of KS spindle cells [8].
The genes SALL4 and TM4SF5 were expressed to a higher extent in the tumours from deceased patients in our material and have been reported to be up-regulated in other cancers, and may thereby represent putative oncogenes [ 41, 42].
The strong conserved blue peaks upstream of pri-miRNAs may represent the putative promoter regions.
Overall, these data suggest that EGFRtyr1068 may represent a putative additional biomarker for EGFR TKI sensitivity in LCSCs.
This suggests that FP-altFP receptor heterodimerization may represent the putative prostamide receptor (Gandolfi and Cimino, 2003; Woodward et al., 2003, 2007; Matias et al., 2004).
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