It was recently claimed that an ill-posed null hypothesis may lead to the false identification of significant network patterns, as such a randomization process may not correctly represent naturally evolved networks [ 7, 8].
There is an alternative possibility that the lower minor band may represent the naturally degraded form of LASP-1.
These cells are capable of directly generating Tr1 cells in vitro and in vivo, and may represent a naturally occurring dendritic cell subset involved in eliciting tolerance in vivo [ 41].
This may represent a naturally occurring allele, but since the mutated residue is conserved in human, chimp, bovine, equine, and rat COMP, the cDNA sequence was corrected by site-directed mutagenesis using the QuikChange kit (Stratagene, La Jolla, CA, USA) and primers FwdMUT (5'-CCCCCTGGGTTCAGCGGGCCCACCCACGAGGGCGTGGGACTGACC-3') and RevMUT (5'-GGTCAGTCCCACGCCCTCGTGGGTGGGCCCGCTGAACCCAGGGGG-3').
These data also confirmed that these epitopes identified by predictive algorithms are likely to represent naturally presented epitopes and may therefore be significant for the design of peptide-based vaccines.
These cell lines represent naturally occurring TRAF3-/ tumor B cells.
These mixed infections most likely represent naturally occurring reassortment among RV strains [ 4, 5, 25].
The β-carbolinium species are neurotoxic substances [ 30, 33], and therefore this oxidation may represent a new route of activation of naturally occurring 2-methyltetrahydro β-carbolines, which could be of significance for the toxicological fate of these substances.
First, we identified sequences that do not appear to consistently group with apparent barcoded conspecifics; these sequences may represent curation errors, artifacts, or chimeric sequences generated naturally.
