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These pathways may have arisen due to convergent evolution, or may represent modifications of an ancestral pathway.
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Such change in representation may therefore represent modification of synaptic inputs [ 13].
The identity of these higher molecular weight band is unknown at present but may represent posttranslational modification such as ubiquitination.
In the case of pre-miR-21 and pre-miR-29a, although most of 3' ends could be assembled into a perfect RNaseIII-cutting end with its 5' ends, small percentage of 3' ends had variations (Table 2 and Figure 1B) that may represent a modification after Drosha processing.
These represent modifications of the conclusions of Kerr [op. cit.].
The three locations Northern Sea, Baltic Sea and Western Atlantic/USA are genetically unified by one lineage (BOR, cf. figure 2) and here phenotypic differences may represent environmentally mediated modifications.
Nur77 protein is recognised by western blot analysis as multiple bands as previously reported in different studies, and the slow-migrating bands may represent post-translational modifications (Kolluri et al, 2003; Han et al, 2006).
The slower migrating band (minor band) may represent a posttranslational modification of EGFP-UL76 fusion protein.
We can speculate that this stress-induced Prdx6 population may represent an adaptive modification of the Prdx6 protein to limit its overoxidation and to maintain its antioxidant activity in response to a strong oxidative burden.
Although still to be characterised, this may represent some posttranslational modification of the Brn-3b(s) protein expressed in the heart in response to the injury model used.
Even though electrospray ionization can produce oxidation, given that a similar analysis of the Dam1 complex did not show any obvious oxidation, the oxidized Pyrococcus furiosus proteoforms may represent an endogenous modification.
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