Sentence examples for may represent mediators from inspiring English sources

From previous work examining the properties of topological bottlenecks in networks inferred from global transcriptomics data we have postulated that bottlenecks may represent mediators of transitions between states of the system [ 1, 28- 30], and therefore represent critical points of control for the disease process.

Hypoxia and PGs have been associated with these increases in VEGF expression (Fan et al., 2008; Maybin et al., 2011b) and may represent downstream mediators of progesterone withdrawal.

Inside of these pathways, several gene targets have been identified that may represent key mediators in the development of endothelial dysfunction and progression to shock.

Model II included these variables plus baseline BMI (kg/m as the original BMI and its quadratic term [BMI]) because this may represent a mediator in this diet diabetes relationship.

The accumulating lines of evidence on the phenomenon known as lipotoxicity [ 49] indicate that the hepatotoxic effects of free fatty acids may represent further attractive mediators of this process.

However current data suggest that endotoxin may represent an important mediator for inflammatory related metabolic risk.

Given the observed function of AP4 in transformation, AP4 may represent an important mediator of cellular transformation in human malignancies.

Thus, elevated HGMB1 may represent another important mediator of the effect of HLA-B*35 on immune dysregulation in lcSSc patients.

Based on these results, we believe serum AP may represent an important mediator and potential therapeutic target following cardiothoracic surgery in infants.

Therefore, this bacterial protein may represent a critical mediator of systemic inflammation and intestinal barrier failure in sepsis due to flagellated micro-organisms.

Although the role of IL-33 has not yet been fully investigated in the pathogenesis of intestinal fibrosis, several lines of evidence indicate that the IL-33/ST2 axis may represent an important mediator in this process.