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The genetic variants involved may be rare or common and may represent loss or gain of function.
Thus, heterozygous BRCA1-methylated cases may represent loss of methylation from an earlier homozygous BRCA1 methylation and HR-deficient state, contributing to PARPi resistance.
On the one hand, selective logging may represent loss of important habitat, yet, on the other hand, selective logging may increase browse availability for a terrestrial ungulate prey base, thereby indirectly benefiting large carnivores.
This loss of approximately 20% radioactivity at these temperatures may represent loss from low affinity binding sites to 99mTc.
Since VDR is expressed in granulosa and corpus luteal cells [32], the ovarian failure we observed in mice 12 months and older may represent loss of VDR regulated gene expression within ovarian tissue.
Alternatively, it is possible that loss of TRPV4 expression in vascular smooth muscle may represent loss of a vasoconstrictor mechanism.
Similar(52)
Hv- Clo3 was not identified in the barley data sets in GenBank; this may represent gene loss, loss of gene expression or may be due to incomplete transcriptome or genome sequence from these species in the current databases.
Going through a breakup is painful because it may represent the loss of not only the relationship, but of any shared hopes and commitments.
In the US it has been estimated that the minimum cost of turnover may represent a loss of over 5percentnt of the total annual operating budget, due to hiring and training costs and productivity loss [ 14].
This means that the current collection efficiency from that layer is low, and may represent a loss in a real device, due to absorption of light in a poorly photoactive layer.
This reduced exploratory activity may represent the loss of interest in new stimulating situations and may imply the presence of motivational deficits.
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