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In particular, E2F1 over-expression observed in BL cases lacking the typical translocation may represent itself an appealing possible mechanism able to determine c-Myc over-expression and sustain it at high levels in the absence of translocation, due to the existence of a feedback loop responsible for controlling the reciprocal expression of these transcription factors.
Of course we do not intend to propose that NF- κB activation may represent itself a target for antidepressant drugs.
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The work itself may represent realities that people find immoral or disturbing.
Pachycephalosaurus possibly co-existed alongside additional pachycephalosaur species of the genera Dracorex and Stygimoloch, though these may represent juveniles of Pachycephalosaurus itself.
T1-mediated inflammasome activation is in line with recent work by others and suggests that the T1 system itself may represent the basic caspase-1 activating stimulus in RAW264.7 macrophages which is further enhanced independently by SopE and/or flagellin.
More recently, the possibility has been raised that noise itself may represent a separate conduit of information in addition to the mean input current to a neuron [26] and the consequences of embedding information in this information channel have been studied [18], [27] [29].
Metastasis microenvironment conditioned by the tumor itself, may represent an alternative to the "seed-soil" theory.
Regulating wound angiogenesis in itself may represent a means for improving healing in some cases, particularly where delayed or defective angiogenesis is implicated in healing impairment.
In fact, obesity itself may represent a low grade systemic inflammatory state and could thus favor different immune and inflammatory responses.
On the contrary, particularly in the early phases of the disease, noise itself may represent a target for etiologic therapies, and might ultimately turn out to be less complex to attack than genes or viruses.
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