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Whether increasing fibrinogen levels can restore hemostasis in this context is not established but may represent increased platelet glycoprotein fibrinogen binding, altered adenosine diphosphate (ADP -dependent plADP -dependention, or an increase in formation of soluble fibrin as a complateletf whole blood clot.

In the papers finding differences, one included patients who were not clearly euthymic, and findings may represent increased impulsivity due to the participants' mood state.

Increased mitochondrial matrix density can be due to a loss of water and ions (condensed conformation), but also may represent increased matrix protein content [15].

This may represent increased innate immune activity of WT cells, perhaps mediated by detection of some damage associated molecular patterns generated by stressed cells in vitro [32], although cell survival was not grossly affected by LPS treatment for 24 h.

Baseline defects predicted site-specific BML progression, which may represent increased bone loading adjacent to defects.

Therefore, strong expression of survivin in the nucleus may represent increased mitotic events.

This may represent increasing professionalization of fisheries so that households which rely on fisheries had less supplementary occupations at higher levels of development.

For example, Figure 2c shows a scenario in which exposure is reduced gradually (by 5% per year rather than rapidly as in Figure 2a) which may represent increasing coverage of ITNs or additional interventions being implemented for example regular indoor residual spraying (IRS).

The diminishing odds ratios with increasing age may represent increasing resiliency, or may reflect clinical differences that exceeded the scope of this study to evaluate.

In conclusion, we suggest psychrophilic fungal species probably will continue to be major pathogens of ectothermic vertebrates, whereas fungi with thermal tolerances closer to endothermic body temperatures may represent increasing threats to endotherms.

Passive evolutionary trends may represent increases in overall diversity among component lineages over time, but one in which expansion is limited to a single direction for example, if ancestral species exhibit small bodies near the minimum possible size then diversity can only expand in the direction of larger maximum size (Fig. 6; Stanley 1973).