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Such sequences may represent genomic architecture that is prone to genome instability by a predisposition to genomic rearrangements via non-homologous end joining (NHEJ), template switching and/or non-allelic homologous recombination (NAHR).
These two putative cDNAs are unspliced, lack major polyadenylation signals, and end in a stretch of polyA mouse genomic sequence, suggesting that they may represent genomic DNA contaminants.
CABOG's extra sequence may represent genomic repeats.
In addition, sequences traced to copia and gypsy-like retroelements were reported as being very frequent in Pinus contorta ESTs [ 32] and were overrepresented in a root xylem cDNA library [ 33], although some of these sequences may represent genomic contaminations [ 13].
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While these reads may represent true genomic regions, the difficulty in assigning them to a particular genomic region limits their value.
Unlike genetic variation, epigenetic changes generating novel and heritable phenotypes may represent reversible genomic alterations that allow colonizing variable environments and new landscapes on an evolutionary timescale [7], [16], [17].
These findings indicate that 1q23 amplifications are heterogeneous and may represent different genomic events with no common target region.
Although many of these may represent true genomic duplications it is also possible that some may result from artifacts in the current draft genome assembly.
We hypothesize that the specific satellite sequences inherent to the Cathartidae may represent unique genomic signatures that could help resolve the long disputed taxonomic position of this avian family (e.g., [ 55, 57, 58]).
More interestingly, GI1 may be significant for the evolution of the Xf group, since all studies undertaken so far, involving a total of 10 different South American strains, obtained from both citrus and coffee, indicate that this element may represent a genomic sinapomorphy for the South American Xf strains [ 26].
This region is located near the end of the short arm of chromosome 8 and contains a high proportion of LTR-retrotransposons similar to observed in the centromeric region of this same chromosome, and thus may represent a genomic region that has recently switched from euchromatic to heterochromatic states.
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