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The non-African component, which includes the SLC24A5 allele associated with light skin pigmentation in Europeans, may represent gene flow into Africa, which we estimate to have occurred ∼3 thousand years ago (kya).
These may represent gene models that are more prominently expressed during later stages of heart development.
Additionally, some of these may represent gene families important in cattle adaptation or recent domestication.
Some of the double crossovers over a short distance (i.e. within 1 Mb), which we ignored may represent gene conversion.
Given that unique region 13 does coincide with a BDI peak (Fig. 2A), it may represent gene acquisition by strain DJO10A.
The divergent gene structures in the different phylogenetic subgroups may represent gene family expansion from ancient paralogs or multiple origins of gene ancestry.
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They may represent genes and pathways commonly activated in tumors compared to normal tissue.
Genes that are induced under CF conditions in J2315 may represent genes with changes in regulation or those acquired since the strains diverged.
Because there is little genomic data for Gnathifera the transcripts we found with no known function may represent genes that are species-, class-, phylum- or even superphylum-specific.
SignalP software predicts the presence of putative signal peptides within 11,064 contigs indicating that they may represent genes encoding secretory proteins.
We believe that specific differences in gene expression that are noted by others may represent genes that are most affected by changes in the large-scale organization of gene expression levels.
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