However, a number of island proteins share high sequence identity and contain conserved domains which suggest they may represent T6SS effectors with putative functions in host-microbe and inter-bacterial interactions (Additional File 1 Table S1).
We postulate that this T-cell subset may represent circulating effector cells that may play a role in promoting the chronic inflammatory process.
Thus, p66Shc may represent an effector of glucose transport in skeletal muscle cells and confirm to play an important role in the adaptive responses to environmental factors [ 97].
This suggested that miRNAs would not be the initiators of the PR degeneration process but instead may represent co-effectors and/or arise in response to retinal disease progression.
A calcineurin binding protein identified in C. neoformans is conserved in yeast and humans and may represent a calcineurin effector or inhibitor.
To evaluate whether the CD25+CD4+ T cells may represent either active effector T cells or immunosuppressive Treg cells [ 21], intracellular staining and flow cytometry detection of Foxp3, Treg cell signatory, [ 22] were carried out.
Our results imply that the suppression of the major downstream effectors may represent feasible strategy for glia-targeted therapy of glaucoma, ensuing further experimental validation of these targets.
Thus, MYD88 mutants, as well as their downstream effectors, may represent promising therapeutic targets for these diseases and need to be further investigated in detail.
Thus, our report in support of previous studies [45], [46] suggests that cyclin D1 may represent a final common effector for mitogenic signaling via KGF receptor.
Since IL-17 production reaches the highest levels during the immediate early phase of the immune response and the activation of Th17 cells precedes the Th1 cell differentiation we tent to speculate that this particular Th cell subset may represent a first line effector Th cell subpopulation.
