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This has been attributed to a defect in innate sensing, which leads to unstable gut microbiota and low-grade inflammation, which may represent drivers for chronic colitis [ 64].
Potential genomic markers of interest were identified on chromosomes 1p, 2p, 5q, 8p, 11q, 14q, 18q and 22q and may represent drivers involved in oral cancer progression.
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However, these genes may represent additional drivers and targets of amplification.
Genetic alterations in sequential OPMLs and same-site OSCCs may represent key driver changes in disease development.
Some frameworks also represent drivers of human health beyond those related to ecosystems.
Recent literature in the field of cultural economics highlights a possible inversion in the usual causality relation (from economic growth to culture) and points out that culture may represent an important driver of economic growth.
Together, such environmental drivers may represent key mechanisms underpinning species mono-dominance (or 'invasiveness') at the whole-ecosystem scale (Peh et al. 2011; Richardson et al. 2000; Rout and Callaway 2009; Wardle et al. 2004).
A study of comparative genomics between the orangutan and primate genome revealed that a pristine shared insertion with three orangutan-specific and three human-specific mutations in two lineages may represent an ancient backseat driver of Alu element expansion [ 12].
Interacting with a device with the vehicle temporarily at rest may represent a distinct form of driver distraction.
Since we considered associations to signaling pathways such driver pathways may represent a core that governs the change of the signaling apparatus in GBM.
Based on our findings, the core gene set may represent a series of cancer driver genes that directly impact a patient's cancer severity.
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