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Such foci may result from the loss of genetic material with γ-H2AX signal being located at a chromosome broken end or may represent DNA lesions complexes, perhaps including clustered lesions.
Many of these sequences may represent DNA integrations into mosquito genomes.
The 2 samples positive by initial microscopy, but negative by PCR, may represent DNA degradation over the prolonged period of frozen storage before testing.
The 4 VPaI regions examined may represent DNA acquired by the pandemic group of V. parahaemolyticus isolates that increased their fitness either in the aquatic environment or in their ability to infect humans.
The CL34 arrays within these signals can be grouped into five size categories with average sizes of 34.9 ± 0.6 μm (n = 4), 80.3 ± 0.9 μm (n = 20), 146.2 ± 6.0 μm (n = 5), 198.1 ± 1.0 μm (n = 5) and 289.6 ± 12.0 μm (n = 4), respectively, which may represent DNA loci at different chromosomal ends.
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The appearance of novel elements in multiple contexts suggests that they may represent DNA-binding sites for additional factors that are essential for enhancer function.
The HBoV DNA detected in our study may represent persistent DNA from past infection; however, history of recent respiratory or diarrheal infection was absent.
This supercontig may represent phage DNA rather than mitochondrial due to the lack of alignment with the mitochondrial DNA.
These two putative cDNAs are unspliced, lack major polyadenylation signals, and end in a stretch of polyA mouse genomic sequence, suggesting that they may represent genomic DNA contaminants.
The final 9 bp (AACCTATGT) of the 734-bp insertion may represent filler DNA (see bottom panel of Figure 5).
As the reviewer points out, even though the KEGG maps consist not only of proteins but also of RNA, DNA and small molecules, and even though some of the interactions may represent protein-DNA interactions we do not focus on these.
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