As SOX7 is also expressed later during development in tissues such as lung, liver, and a number of mesodermal cell types [42], the increase in SOX7 levels in hESC may not represent differentiation towards VE/PE.
The accumulation of C6 cells in the G1 phase may represent a differentiation process leading to differentiated astrocytes.
These findings suggest that CD4+ and CD4− NKT cells may represent unique differentiation states.
Lack of GARP expression further differentiates and explains the transient nature of TGF- β-induced iTreg cells [ 19], suggesting that natural and iTreg cells may represent alternative differentiation stages of suppressor cells [ 21, 26].
Importantly, the downregulation of miR-122 was detected in more than 70% of cases of HCC [ 29], which may represent either a differentiation reversion or a block to a less-differentiated status of liver cells.
The purposeful manipulation of exterior atmospherics may represent a viable differentiation strategy in a competitive retail environment (Cornelius et al. 2010), especially for independent retailers operating in downtown shopping districts (Grewal et al. 2003; Mower et al. 2012), who may lack the visual brand recognition of national retailers.
The slightly higher expression of CDKN1C in the trilaminar placenta may represent the terminal differentiation of haematopoietic tissue in this region that requires exit from the cell cycle.
Interestingly, re-expression of these specific miRNAs, such as miR-1 and miR-206, impaired the tumorigenic behavior of RMS cells in vivo, raising the possibility that miRNA re-expression may represent an effective differentiation therapy for RMS.
This divergence is greater than the divergence seen between two recognized species D. delphis and D. capensis in both mtDNA and AFLP data and may represent species level differentiation [ 42].
Although there is data to suggest that CD7-negative T-cells may represent a distinct differentiation pathway in normal and neoplastic helper T cells,[ 20, 21] the variable expression of CD7 in MF/SS that we have observed suggests that this marker may be highly modulated by tumor microenvironment and/or treatment.
