Generally, it is stated that patients with chest pain and normal coronary arteriogram may represent 10 20% of those undergoing coronary arteriography because of clinical suspicion of angina [ 65].
Complex coronary artery bifurcation lesions occurred in hard clinical scenarios, such as acute coronary syndromes, may represent a challenge for interventional cardiologists, with not-defined general consensus on treatment.
Our findings suggest that these miRNAs may have a role in the pathogenesis of coronary bifurcation lesion and may represent novel biomarkers for the diagnosis and prognosis of coronary bifurcation lesion.
Moreover, monitoring of DCs and its subsets may represent a novel strategy to detect acute coronary syndrome in human type 2 diabetes.
Furthermore, the flattening of the decline in mortality for coronary heart disease among younger adults may represent an early warning sign.
These results show that Paigen-diet fed PDZK1/apoE dKO mice represent a new animal model useful for studying coronary heart disease and suggest that PDZK1 may represent a valuable target for therapeutic intervention.
Thus, the Paigen diet-fed PDZK1/apoE dKO mice represent a new murine model of coronary heart disease and suggest that PDZK1 may represent a valuable target for therapeutic intervention.
Possibly, these values represent irreversible hemodynamic collapse, with inadequate coronary or myocardial perfusion pressure, or they may represent perfusion pressures supplied too late (after the haemodynamic phase), with consequent irreversible tissue damage [ 27, 28].
Moreover, the truly noninvasive, inexpensive, and radiation-free nature of CIMT may represent an important advantage over other suggested screening techniques such as coronary calcium scoring (5).
However, the fact that all subjects were referred for coronary angiography, albeit electively, and that many had relatively preserved renal function, also may represent some degree of selection bias and may not be fully representative of the broad population of patients with diabetes mellitus in clinical practices.
