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Alternatively, expression differences may represent compensatory changes in pathways and networks.
The authors speculated that areas of increased positive FC with visual cortices may represent compensatory recruitment or diminished inhibitory input.
Subsequent findings [ 60] indicated that decreases in leptin and melanocortin signalling may represent compensatory responses to manage chronic stress at the expense of metabolic derangements.
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The exact mechanism is unclear but may represent a compensatory phenomenon.
The increase in XA, a putative activator of Glu2 receptors, may represent a compensatory event aimed at reinforcing endogenous analgesic mechanisms.
Hence, the increase in XA levels we have found in CM patients may represent a compensatory event aimed at reinforcing endogenous analgesic mechanisms in migraine.
We speculate that the increased metabolism in the precuneus in our patients may represent a compensatory mechanism for the naming difficulties, which warrants further study.
This latter may represent a compensatory response to the excessive local availability of NO, released directly by GTN or synthetized by nNOS.
Higher magnitudes of the BOLD signal in older adults may represent a compensatory pattern to counter age related deterioration in motor control systems.
KYNA reduction and QUINA increase are consistent with the hypothesis that NMDA receptors are overactive in migraine, and the increase in XA levels may represent a compensatory event aimed at reinforcing endogenous analgesic mechanisms in migraine.
Notably, recent studies indicated that enhanced glycolytic capacity in individual myofiber strongly correlates with whole body insulin sensitivity (Nader and Esser, 2001; Oberbach et al., 2006; Izumiya et al., 2008), suggesting that activation of the glycolytic myofiber program may represent a compensatory mechanism in response to increasing glucose level in type 2 diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com