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Despite the growing realization that CM is a complex multisystem disorder, our data suggest that angiopoietins meet several of these criteria and may represent clinically useful biomarkers for this syndrome.
Lipid rafts function as platforms for the formation of multicomponent transduction complexes and they may represent clinically relevant potential targets for immune regulation [ 14].
There is growing recognition of particular genes for which there is consensus that mutations in those genes may represent clinically significant incidental findings [ 57, 58].
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Despite the statistical significance of time trends and differences in age-specific susceptibilities, the magnitude of these differences was generally less than 5% and thus may not represent clinically meaningful differences.
However, studies of the score profiles of various clinically defined patient groups have suggested that a 3 5 point change in scale scores may represent a clinically important difference [ 34- 36].
Together, these data suggest that scaffolds which persist throughout the remodeling phase of repair may represent a clinically translatable method to prevent HSc contraction.
In summary, data presented here demonstrate that TGF-β3-bound hyaluronan microspheres provide a suitable delivery system for induction of hMSC chondrogenesis and their use may represent a clinically feasible tissue engineering approach for the treatment of articular cartilage defects.
Conclusions: We conclude that scoring of hemorrhage is possible in children with ITP and that the grade of hemorrhage may represent a clinically meaningful end point in future studies.
We conclude that reduced responses to IL-7, reflected by pSTAT5, may represent a clinically relevant functional biomarker for individuals at increased risk for CMV reactivation; our data may also aid in designing better strategies to improve anti-CMV immune responses without increasing the risk of developing graft-versus-host disease.
RNA aptamer technology targeting OPN may represent a clinically viable therapy.
Given the importance of integrin signaling in the regulation of angiogenesis, indirect targeting of integrin function may represent a clinically useful approach for controlling aberrant neovascularization such as tumor angiogenesis.
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