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One has to bear in mind however, that our tissue specimens may represent chronic UV stimulation.
This measurement is an indicator of cumulative lead exposure and is particularly relevant to the elderly in whom elevated bone lead concentrations may represent chronic toxicity [ 3].
Dust measurements may represent chronic residential pesticide exposure because chemicals in indoor dust resist degradation due to limited sunlight, microbial activity, and moisture (Lewis et al. 1994; Simcox et al. 1995).
In this way, they align with the concept of 'serious adverse events' often used in clinical trials, although they may represent chronic conditions and/or be unrelated to cancer-directed therapy.
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These tissues may therefore represent chronic reservoirs from which EV propagates to other organs, such as the pancreas, leading overtime to beta cell autoimmunity.
Therefore, the expression of VEGF mRNA observed in bladder tumours may reflect current hypoxia, whereas expression of CA IX may represent more chronic hypoxia.
These axonal changes may represent a chronic axonal reaction to demyelination (Waxman, 2008; Young et al., 2008; Mahad et al., 2009).
Although similar analysis of HLRCC kidney tumours does not yet exist, these findings certainly support the possibility that elevated fumarate levels may represent a chronic cellular response to impaired/absent FH activity.
It has been hypothesized that several otherwise unexplained chemical-associated illnesses, such as multiple chemical sensitivity syndrome, may represent mild chronic cases of porphyria or other acquired abnormalities in heme synthesis.
The first mechanism may be common to both tests, the fibrinogen level can represent chronic inflammation which may impaire fibrinolytic balance [ 16].
The concentrations found in controls were not associated with acute symptoms and may have represented chronic exposure to aflatoxins.
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