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Similar conclusions have been drawned very recently suggesting that the differences observed between ESC and iPSC are not conserved, and rather a reflection of a laboratory-bias (which may represent cell of origin, cell culture, reprogramming method).
Furthermore, A-type lamin proteins are found only in a minority of cells from the bone marrow, thymus, spleen, and lymph nodes, which may represent cell types of the stroma such as epithelial cells, pericytes, inflammatory cells, fibroblasts, endothelial cells, and smooth muscle cells [8], [13] [15].
The reason for differences in this pattern is not clear but may represent cell and tumour specific differential utilisation of the FRS proteins.
Endothelial/epithelial cell ICAM-1 participates in the migration of leukocytes out of the blood in response to pulmonary inflammation, whereas alveolar macrophage ICAM-1 may represent cell activation.
This sample may represent cell abnormalities prone to regression, as a consequence of HPV expression being switched off: regression of abnormal cytology in women with a positive HPV test at baseline is often associated with viral clearance (Nobbenhuis et al, 2001).
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This may represent cells with insufficient Cre expression, Cre activity, or GFP level.
The second group of GFP positive mRGCs may express very low level of melanopsin representing the M2 type of mRGCs [23], or may represent cells where melanopsin promoter is almost silent in adulthood.
Because it is difficult to distinguish cells in G1 from very early S-phase by FACS, the increased G1 population in Slbp mutants may represent cells that are progressing very slowly through early S-phase.
However, DNAJC6 and RASGRF1 showed differential methylation between trophoblast and mesenchyme, which may represent cell-type-specific imprinting.
Instability-correlated pathways may either directly modify instability or may represent cells' secondary responses to instability.
Other finding indicated that DBA+ and DBA− uNK cells may represent cells arising from different sources, and DBA+ uNK cells may represent cells arising from homed progenitor or precursor cells.
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