Aberrancies in the E2F pathway are one of the hallmarks of human SCLC [3], [4], [30], [57]; therefore, nutritional agents like capsaicin, which target the E2F pathway, may represent new avenues for the treatment of lethal malignancies like small cell lung cancer.
We also show that EGFR levels return to control levels within a few days, therefore strategies to augment EGFR signalling may represent important avenues to pursue to initiate a robust response from the resident SVZ NSPs following injury for functional brain recovery.
However, because of their role, miRNAs may represent another avenue for therapeutic intervention in arthritic diseases.
Therapeutic peptides that can target the mitochondria of cancer cells and induce cell death hold significant promise and may represent an avenue to restrain migration and metastasis.
Leveraging available literature models for marketed cytotoxics and targeted therapies with nascent models specifically developed for CIT may represent an avenue to inform optimal CIT combinations.
A growing usage of electronic resources may represent an avenue to link national EBM educational expertise, facilitating future collaborative educational efforts.
A growing usage and support of web-based resources may represent an avenue to link EBM educators across Canada, and respond to the desire expressed by program directors to create a national unified EBM educational resource.
While we observed relatively low expression of ErbB2 in our samples as compared to an MMTV-NIC control lysate, the strong levels of phosphorylated ErbB2 in the doxycycline-independent rtTA/MIC recurrences may represent an avenue of recapitulating the signalling associated with PyV mT tumourigenesis in the absence of transgene re-expression.
The lines represent avenues or streets.
Gene therapy may represent a new avenue for the development of multimodal treatment for diverse forms of cirrhosis.
