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These truncated peptides may represent alternate cleavage products by β- and γ-secretases or products of Aβ degradation.
Both aberrations are expected to affect H3K36me2 signaling and may represent alternate pathways to the same molecular endpoint.
It is possible that suicidal ideation or an attempt preceded engagement in NSSI and/or firesetting; these behaviors may represent alternate expressions of psychological distress or attempts to distract from suicidal tendencies [ 10].
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The calcimimetic cinacalcet HCl (cinacalcet), which lowers PTH and calcium (Ca) in chronic kidney disease patients, may represent an alternate therapeutic modality.
The MDA-MB-330 cell line expresses wild-type but dysfunctional E-cadherin due to a biallelic mutation in α-catenin (CTNNA1), which may represent an alternate mechanism to impair E-cadherin function [ 46].
Considering other novel approaches to attain participants willing to act as patients may represent an alternate, yet effective, approach in attaining a pool of volunteers on a continual basis.
Our data offer support to the suggestion that Stages 2 and 3 sit on a continuum, while Stage 4 may represent an alternate phenotype as this group is significantly older at onset and has a shorter disease duration.
We suggest that the increase in calcium in ASEL may result from rapid signaling downstream of PI3-Kinase acting directly on calcium channels (Blair and Marshall, 1997), and that this may represent an alternate pathway to the canonical, long term effects of DAF-2 signaling to regulate gene expression (Murphy et al., 2003).
These sensitivity analyses represent alternate perspectives for decision making as valuations placed on QALYs and bed-days by decision makers may vary.
In the grid, lines represent alternate notes of the scale and the spaces the intervening notes.
Six of the ten cases represent alternate intron removal or retention; the other four represent alternate splice junction usage (two 5', two 3').
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com