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We speculate that, by comparison to wild-type, the strongly centrosomine-stained structures detected in Figure 4, D F may represent aggregates of duplicated centrioles, either unable to move apart or separated in an earlier event but then replicating without disjunction.
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After annealing, rather homogenously distributed bulges appear on the sample surface which may represent crystal aggregates of porphyrin molecules formed onto the gold surface during porphyrin evaporation (see Figure 3B).
Instead, their interiors appear to be filled with more irregularly shaped larger clusters that may represent protein aggregates with compromised enzymatic activity.
In addition, no diffuse cytoplasmic AS-PLA signal was observed in controls, indicating that this type of staining is strictly pathological and may represent early aggregates that precede currently recognized pathology.
These puncta likely represent aggregates of individual gap junction channels.
The discharging grains represent aggregates of bacterial filaments or fungal hyphae.
Recently, this hypothesis has been challenged by findings suggesting that fibrillar aggregates may represent inert dead-end products of the Aβ42 aggregation pathway.
CD shows that the soluble aggregates differ dramatically in secondary structure compared to native MstnPP and that the aggregates may represent an α-helical-containing intermediate in the transition to protofibrils and fibrils rich in β-sheet structure.
Alternatively, these aggregates may represent extra-accumulation of pericentriolar material without centriole replication.
The increased tendency of mHtt to aggregate may represent an exaggerated behavior of an inherent property of wt Htt.
These findings show how polyA CC peptides can form fibrillar structures that organize into progressively larger bundles and tangles, which may represent the ultrastructural substrate for aggregate formation in vivo.
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