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Both TIC cell types had mutations in either BRAF or KRAS and both in PIK3CA genes that may render patients insensitive to treatment with signal inhibitory anti-EGFR therapeutics [45], [46].
Thus, cytoreduction achieved by chemotherapy may render patients more amenable to RIT.
Accordingly, selective targeting of Th17 pathways may render patients clinically susceptible to OPC or other mucocutaneous manifestations of this fungus.
Anemia, acidosis, respiratory compromise, and cardiac disease may render patients more susceptible than expected for a given methemoglobin level.
Advance directives may be especially useful among patients with COPD because of their likely trajectory of illness, with unpredictable exacerbations that may render patients suddenly critically ill.
We suggest that the hospital continuously maintain the lighting systems in the waiting areas or centralize the waiting areas when some offices are closed and patient volume is lower; these actions may render patients less lonely or afraid.
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It is therefore plausible to suggest that the use of non-specific SFK inhibitors in the treatment of malignancies may come at a price of inhibiting host immune resistance against tumor cells, and may even render patients vulnerable to infections.
As the compromised immunity in cancer patients may render cancer patients susceptible to new tuberculosis infections or reactivations (Wu et al, 2011b), another explanation is reverse causality; tuberculosis was diagnosed before cancers that actually predated the tuberculosis infections, leading to the increased SIRs within the first year.
Even if dyspareunia patients would report a strong attenuation of dysfunctional beliefs after treatment, residual dysfunctional automatic associations may remain and render patients vulnerable for relapse.
Tamoxifen itself does not affect the ovarian reserve, but the delay in attempting pregnancy for 5 10 years may render some patients infertile by virtue of the impact of aging on their already diminished ovarian reserve.
Prospective planning is required in view of a potential future functional decline which may render the patient dependent for the activities of daily living.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com