Sentence examples for may render neurons from inspiring English sources

Such effects may render neurons susceptible to stress, and are known to contribute to the reduced neuronal viability seen in PINK1 knockdown/KO mammalian neurons (18).

Thus, the enzymatic activity of QC appears to be a prerequisite for pE-Aβ peptide generation and QC expression may render neurons especially vulnerable.

Our results strongly suggest that phospho-TDP-43 aggregates are associated with neurotoxicity in that they have co-localization with activated caspase 3. Igaz and colleagues suggested that loss of murine TDP-43 within the nuclear compartment may render neurons in inducible TDP-43 mice susceptible to neurodegeneration [ 19].

Collectively, these reasons may render midbrain neurons more sensitive to neuronal death via oxidative inactivation of m-aconitase.

"Normal" aging may render striatal neurons more vulnerable to mutant Htt toxicity.

Therefore, the life-long reliance on L-type Ca2+ channels may render DA neurons particularly vulnerable to perturbations in mitochondrial Ca2+ buffering capacity.

This may render aged neurons more susceptible to cell death in late onset neurodegenerative diseases.

Among these potential factors, dopamine (DA), which is found at high concentrations in the striatum, may render striatal neurons highly sensitive to mutant Htt (13).

This may render GnRH neurons less able to respond to afferents that rely upon them to convey signals to the maternal circuitries.

The age-dependent down-regulation of metallothioneins may render DA neurons susceptible to oxidative stress and Charnoly body formation, an early and universal mitochondrial biomarker of cell injury, apoptosis and progressive neurodegeneration.

These changes render neurons more vulnerable to a second insult.