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In the final stages of life, symptoms may remain refractory.
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A high DAS28-CRP composite score may be inflated by higher tender joint count and patient-reported global health assessments, which in this case will remain refractory to effective anti-inflammatory therapy.
Despite the equivalent efficacy and better tolerability of these drugs, more than 25% of patients remain refractory to treatment.
11 However, there is still a significant population of patients who remain refractory to this therapy.
A high proportion of these remain refractory, necessitating the use of anesthetics [ 12, 16– 16].
151, 152 That leaves 30% of cases that still remain refractory to effective treatment, despite drug development.
The mechanism by which most acinar cells remain refractory to Kras G12D -mediated transformation has not been elucidated.
Despite recent advances and wide availability of anti-TNF agents, a considerable number of patients remain refractory to treatment [ 5- 7].
Even with their use, a high proportion of patients remain refractory, requiring the use of anesthetics [ 81, 85, 213, 214].
However, instead of succumbing, cancer cells often remain refractory to chemotherapeutic drugs owing to the development of drug resistance.
Despite significant increases in overall survival, approximately one-third of medulloblastoma patients will remain refractory to current therapies [ 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com