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Both soft liners and tissue conditioners may release components as residual monomers, plasticizers, degradation products [ 7, 8], and alcohol [ 3, 4].
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Although 2 weeks was enough to produce a sufficient amount of leaching materials to be analyzed by IR spectroscopy, it is likely that all commercially available resin-based dental materials will continue to release components that may cause detrimental effects or alter cellular function in vitro even after 2 weeks of aging in artificial saliva.
Although polymer networks are considered largely insoluble structures, with relatively high chemical and thermal stability, in the oral environment composite resins may absorb water and chemicals from the environment and release components into its surroundings.
Furthermore, the degradation of PLGA-TPGS random copolymer may release the TPGS components, which have synergistic anticancer activity in the presence of anticancer agent [23, 24], thus increasing cancer cell mortality.
Moreover, the degradation of PLA-PCL-TPGS random copolymer may release the TPGS components, which have synergistic antitumor activity in the presence of antitumor drugs [27, 28], thus increasing cancer cell mortality.
The components of silver solder alloy may release toxic ions as well [ 49].
Previous studies have shown that different components of orthodontic appliances, such as bands, brackets and archwires may release metal ions in vivo[5] and under in vitro conditions [28].
The Interview may release now.
Melting the plastic may release toxic chemicals.
(Note that issues for post-release are not related to projects but to released components).
Cementitious materials are considered to come in contact with underground water or bentonite and release alkali components, which may degrade their performance.
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