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Unaltered TNF-α in the studied subjects may relate its dependency on the insulin as the TNF-α secretion was positively correlated with the plasma insulin concentrations [ 39], which is consistent with unaltered serum insulin levels in the subjects independent of BMI.
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Though the effect mechanism of TCM is not very clear, increasing data has shown that it may relate with its action on regulating tumor immune environment, the novel target according to the theory of immunoediting [ 5, 6].
THBS1 has been described with many diverse functions that may relate to its structure and consequently to its ability to bind to matrix proteins, cell surface receptors or other molecules including cytokines [ 51].
This activity may relate to its neuroprotective functions as it reduces cytochrome c release from damaged mitochondria, thereby preventing subsequent induction of the apoptotic cascade (6).
Although recent studies have established the involvement of the cytoplasmic PNGase in ERAD-related events, how this enzyme activity may relate to its biological significance has not been demonstrated in any systems.
The renal effect of Ang II may relate to its selective effects on intrarenal hemodynamics, where it controls tone in the afferent and efferent arterioles [ 14] and mesangial cells [ 23].
Thus, M. tuberculousis is the sole species characterized to date that has a very limited supragenome which may relate to its very recent evolutionary origins, i.e. it simply has not had time to diversify as much as older species.
The afore analyses indicate that B. terrae BS001 has invested considerable genetic luggage in detoxification systems, which may relate to its persistence in ecological niches that are affluent in such compounds and may explain its versatile ecological behavior.
IGFBP-3 is not an independent prognosticator for overall survival or disease-free survival, to reflect its dual effects on breast cancer growth regulated by complex pathways in vivo that may relate to its interactions with other growth factors.
An unusually large number of histidine side-chains are exposed on the surface, which may relate to its location within the crystalline style of the digestive tract of the mussel.
These latter fractions were consistently greater for SUV420H2 and may relate to its higher expression level (Figure 2A).
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