Our results predicted general transcriptional regulators that may regulate gene expression in a global or pleiotropic mode.
Additionally, the expression profiles of putative virulence genes in G9241 suggest that this strain, unlike Bacillus anthracis, may regulate gene expression with both PlcR and AtxA transcriptional regulators, each acting in a different environment.
Since Id-1 is a regulator of transcription, it is not surprising that it may regulate gene expression involving multiple signalling pathways.
The first steps for high-throughput mapping of chromosome architecture in specific cell types are under way to help understand the mechanisms by which genome architecture may regulate gene expression.
Correspondingly, chondrocytes cultured in silk and collagen scaffolds maintained higher levels of cartilage matrix than those in PLA, suggesting that these biophysical properties of scaffolds may regulate gene expression and the response to inflammatory stimuli in chondrocytes.
Subsequently, PKA may activate CREB, and CREB may regulate gene expression to stimulate synaptogenesis [69].
The data presented here supports the notion that microRNAs act as post-transcriptional switches which may regulate gene expression when required.
Furthermore, multiple transcriptional start sites and 5'UTRs expressed from a single gene encoding one and the same protein may regulate gene expression through differential expression with respect to developmental stages, tissue type and in response to stimuli [20], [35], [36].
Activation of p38-ATF2 cascades in turn may regulate gene expression to contribute to migration of corneal epithelial cells, as well as of epidermal and mammary epithelial cells [33], [49], [50], [51].
Altogether, these data suggest that in addition to its recognized transcription repression activity, Snail1 may regulate gene expression post-transcriptionally by modulating the level of proteins involved in pre-mRNA processing and location.
