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Estimates indicate that miRNAs may regulate up to one-third of the mammalian genome, suggesting miRNAs have a central role in regulating gene expression [27].
Estimates indicate that miRNAs may regulate up to one-third of the mammalian genome [ 7].
In silico analyses based on complementarity of miRNAs and their putative mRNA targets have led to estimates that miRNAs may regulate up to 30% of protein-coding human mRNAs.
Proteomic and microarray data reveal that although each miRNA may regulate up to hundreds of genes, their effect on individual gene is moderate at best (Lim et al, 2005; Baek et al, 2008; Selbach et al, 2008).
MicroRNAs (miRNAs) are a new class of single-stranded endogenous non-coding small RNA molecules (~22 nucleotides) that bind primarily to the 3′UTR of target mRNAs to repress their translation and accelerate their decay [ 1], and may regulate up to 30% of genes [ 2].
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It has been hypothesized that MYC may have the potential to regulate up to 15% of the entire genome [ 26], leading to it being described as a 'master regulator' of gene expression.
Therefore, attenuating free radical damage with UCP2 help MT antagonize the Dox-induced cardiac toxicity, but does not directly bind MT. MT may regulate UCP2 expression by up-regulating Nrf2.
MicroRNAs are a recently discovered small RNA species shown to regulate gene expression and may regulate the expression of up to 30% of all genes [26].
The 518 human kinases represent an intensively studied class of proteins which may regulate the activity of up to a third of all human proteins by phosphorylation [1].
Beclin 1 containing complexes may regulate autophagy during starvation while Beclin 1-independent complexes may up-regulate mTOR during amino acid stimulation.
Alternatively, FruM may regulate dopamine neuronal activities.
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