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In some cases, lncRNAs may have sequence-independent functions, whereby the action of their transcription alone may regulate transcription of neighboring genes (a phenomenon called transcriptional interference or promoter occlusion) (Kornienko et al., 2013).
Thus, it would not be unexpected that NvCLOCK CYCLE heterodimers may regulate transcription of downstream genes through canonical E-box motifs.
This activity is directed at the core histone H2B, where USP22 may regulate transcription via alterations in levels of histone ubiquitylation [43].
These data provide correlative evidence that the N. vectensis CLOCK CYCLE heterodimer may regulate transcription of target genes through the same DNA motifs that have been identified in mammals and insects.
Preliminary data suggested that nuclear CCN proteins may regulate transcription.
These histone marks may regulate transcription by creating an open chromatin structure and recruit effectors that mediate a transcriptionally competent state.
Similar(43)
Although we cannot rule out RUNX1 binding to other sites in the ESR1 locus, all these data suggest that RUNX1 may not regulate transcription of ESR1 directly.
However, other transcription factors that may regulate the transcription of the Bcl-2 gene, for example c-Myb (38, 39) and STAT5 (40), have not been evaluated in the present study.
Additionally, the two putative MYB transcription factors that may regulate the transcription of the genes identified as being related to lignin biosynthesis, exhibited the same expression pattern (xylem > lignifying stem > bark > non-lignified stem).
Feedback loops in which miRNA-regulated genes may regulate the transcription of their miRNA have been described before [ 23].
LncRNA loci that are transcribed in the developing mouse central nervous system (CNS) show a preference to be located adjacent to transcription factor genes and thus may regulate their transcription (Ponjavic et al, 2009).
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