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Therefore knock-down of Sox2 seems to induce apoptosis, suggesting that Sox2 may regulate survival factors.
Identification of host factors that may regulate survival of pathogens within macrophages has strong implication for developing novel therapeutic approaches.
However, the role of HIPK2 activation in JNK activation upon glucose restriction needs to be further elucidated because several signaling kinases may regulate survival during glu stv.
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Our data suggested that Src may also regulate survival pathways that block apoptosis in hypoxia.
This strengthens the notion that Mcl-1 may not regulate survival as stringently as Bcl-xL in cancer cells treated by antimitotic agents, as this was already observed in cells treated with topoisomerase inhibitors.
It is reported that alternation of O2 microenvironments may regulate hESCs survival, self-renewal, and differentiation capabilities through posttranscriptional regulation of telomerase isoforms [ 16].
Finally, tumor cells acquire the ability to activate several pathways in order to survive and neurotrophin/Trk signal transduction axis as well as JNK pathway may regulate such survival possibilities.
Our data suggests that androgens may regulate osteoblast survival via a PR-dependent mechanism.
However, we can not exclude the possibility that other mechanisms may regulate cell survival and apoptosis in osajin-treated NPC cells.
The core constituents of SGs include components of the 48S preinitiation complex as well as an eclectic group of proteins whose sequestration may regulate the survival of stressed cells [16].
Neogenin is associated with the continuously self-renewing and neurogenic cells present in E11.5 cortical and adult SVZ NS, and the Neogenin/RGMa receptor/ligand pair may regulate cell survival during development.
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