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The notion that distinct subclasses of eIF3 complexes, containing different combinations of core and non-core subunits, may regulate specific subsets of mRNA has been suggested in studies with fission yeast, where biochemically distinct eIF3 complexes defined by the PCI domain proteins eIF3e and eIF3m associate with different sets of mRNAs [24].
Even though multiple target mRNAs can be detected, miRNA may regulate specific mRNAs at specific times and at specific sites.
Moreover, HDACi may regulate specific survival genes, such as p21, which would result in different outcomes depending on the involvement of such genes in the injury model.
Firstly, some LSGs may regulate specific phenotypes or special physiological processes, considering quite a few CSGs and orphan genes with distinct tissue-specific expression.
These data suggest that TR4 may regulate specific subsets of target genes through ETS dependent as well as ETS independent pathways.
Genetic dissection of phenotypical traits, such as formation of egg-laying organs or starvation-resistant dauer larvae, has illustrated how chromatin modifiers may regulate specific cell-fate decisions and behavioral programs.
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Several in vitro evidences have demonstrated that both TP53 Arg72Pro variants may selectively regulate specific cellular functions.
Flexible regulatory patterns indicate that a specific miRNA may regulate selected specific targets and so contribute to specific stages of development.
While gp2 contains the phosphohydrolase and endonuclease activities of terminase, the function of gp3 may be to regulate specific and nonspecific modes of DNA recognition as well as the enzymatic activities of gp2.
Notably, the subcellular distribution of PDE proteins may regulate the specific intracellular localization of cAMP by compartmentalized hydrolysis of cAMP [41].
Furthermore, with greater understanding of the intracellular sites of cysLT synthesis and cysLTR expression and of the functional consequences of such cysLTR-mediated cellular regulation for both intracellular and cell-free granules, newer therapeutic agents may be targeted to regulate specific activities of cysLTs pertinent to asthma and other allergic diseases.
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