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Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspects of Aβ production.
The net neutralizers may regulate some of that, but nobody yet knows how much.
As for other proteins, it appears that staphylococcal nuclease is designed as an assembly of well-integrated foldon units that may define steps in its folding pathway and may regulate some other functional properties.
These results suggest that eIF5A may regulate some aspect of ribosome assembly under normal culture conditions.
Still, PRI 1 may regulate some other genes more distal than these.
However, LIGHT-deficient mice display normal immune responses following infection with Mycobacterium tuberculosis [11] or influenza A [12], suggesting that LIGHT may regulate some cellular responses whilst being superfluous for others.
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Presently, we favor a model in which APP phosphorylation at Thr668 may regulate either some important physiological function of APP that is not directly linked to the proteolytic processing pathways that control Aβ levels in brain neurons in vivo.
The estrogenic compounds in this study may regulate reproduction to some degree in wildlife consuming these seeds [ 38].
Many of these ECM components interact with Itgs, and the defects in Itg activation that we have observed suggest that Tsp4b may regulate assembly of some of these other ECM components (Narouz-Ott et al., 2000; Frolova et al., 2012).
Most astrocyte chemokine receptors are expressed in both primates and rodents, but species differences may regulate receptor distribution for some chemokine receptors.
Slitrk6 may regulate the expression of some of those or other unidentified trophic and/or tropic factors that promote neuronal survival and neurite extension in addition to neurotrophins.
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