Bioinformatic studies suggest that miRNAs may regulate one-third of the transcriptome [10], [11].
This suggests that RPA phosphorylation may regulate the first steps of DSB repair and is necessary for the mediator function of Rad52.
Calcium binding proteins may have a significant impact on signaling processes and regulate second messenger transmission [ 63].
More than 1,400 human miRNAs are known [ 2], and these may regulate about one third of all human genes [ 3].
Estimates indicate that miRNAs may regulate up to one-third of the mammalian genome, suggesting miRNAs have a central role in regulating gene expression [27].
Estimates indicate that miRNAs may regulate up to one-third of the mammalian genome [ 7].
Predictions of targets of miRNAs suggest that they may regulate more than one-third of all genes.
This finding suggests that CR and reduced Tor/Sch9 signaling may regulate common genes, which first promote respiration and depletion of nonfermentable carbon sources and then cause a hypometabolic mode associated with lifespan extension (Wei et al., 2009).
This suggests that a second pathway may regulate proliferation of the TA-cell population.
First, Congress may regulate the use of the channels of interstate commerce.
