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Previous findings have shown that the canonical Wnt3a β-catenin pathWnt3a β-cateninin pathwayts and may regulate platelet functisn [ 34].
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NF-E2 may coordinate with other genes that reorganise the cytoskeleton and transport organelles into proplatelets to regulate platelet release because NF-E2-null mice did not undergo proplatelet formation.
Therefore, it is possible that platelet-derived miR-223 may regulate other immune cells harboring miR-223 target genes via MP transfer and in turn regulate platelet function via platelet-leukocyte interaction (aggregate formation), a process now called immunothrombosis [ 94].
Nesbitt, W.S. et al. Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow.
Nesbitt, W.S. et al. Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.
Nesbitt, W. S. et al. Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow.
PKC activation is generally considered to positively regulate platelet signalling, since platelet activation is inhibited by broad-spectrum PKC inhibitors, and PKC activators can enhance platelet activation.
Although platelets are anucleated cells, apoptotic proteins have been shown to regulate platelet lifespan.
p38 has been suggested to regulate platelet adhesion to collagen and aggregation.
Our data show that PF-573,228 is a useful tool for analysis of FAK function in cells and reveal that in human platelets FAK may regulate a rise in cell calcium and platelet spreading.
In fact, platelet-derived products may regulate COX-2 induction in colorectal epithelial cells and stromal cells (Thun et al., 2012).
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