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Finally, we found 414 miRNAs that may regulate one or several modules associated with clinical improvement.
TF and miRNA may regulate one another and form a composite feedback loop.
It remains to be determined whether nephrocystin proteins may regulate one of these pathways in tubular epithelial cells.
We hypothesized that miR-494 may regulate one or more growth-inhibitory genes to alter cell proliferation.
According to our calculations of all enhancer specific gene, up to 8 nearby genes are regulated by one active cell type specific enhancer, and up to 8 different active cell type specific enhancers may regulate one gene.
Moreover, DNA methylation, histone modification and RNA-mediated regulatory processes are intimately interconnected at a molecular level, and may regulate one another or interact synergistically to reinforce an environmental effect.
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Bioinformatic studies suggest that miRNAs may regulate one-third of the transcriptome [10], [11].
Since expression of an miRNA may be regulated by a TF [ 13], TF and miRNA may reciprocally regulate one another to form feedback loops, or alternatively, both TF and miRNA may regulate their target genes and form feed-forward loops (FFLs).
Here, we present the first evidence suggesting that miR-370 and miR-373 may potently regulate one-carbon metabolism by directly targeting SHMT-2 and MECP-2, respectively.
While several miRNAs may regulate just one mRNA, these results demonstrate another type of regulation where a single miRNA can regulate numerous transcripts, elevating the complexity of cellular processes.
More than 1,400 human miRNAs are known [ 2], and these may regulate about one third of all human genes [ 3].
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