Multicellular glial calcium waves may locally regulate neural activity or brain energetics.
Since Kv2.1 channels mediate neuronal excitability, development, and migration, it is likely that flotillin-1 may also regulate neural excitability and development by modulation of these channels.
Some lncRNAs physically associate with neural TFs such as REST or epigenetic modulators PRC2, implying that lncRNAs may critically regulate neural trans-differentiation.
Given that IGF-1 and the PI3K/Akt pathway can promote cell-cycle progression in vertebrate neural stem cells (Aberg et al., 2003; Yan et al., 2006), this same pathway may regulate vertebrate neural stem cell reactivation in the same way as we have shown here for Drosophila.
Indeed, distinct genetic elements may regulate the neural substrates of behaviors as diverse as courtship and mating, aggression and avoidance, speech, language, and social behavior (Juntti et al. 2008; Robinson et al. 2008; Fisher and Scharff 2009; Siwicki and Kravitz 2009; Wu et al. 2009; Juntti et al. 2010; Robinett et al. 2010).
Thus CSPG may signal via multiple pathways to regulate neural progenitor growth and differentiation.
Shnitsar, I. & Borchers, A. PTK7 recruits dsh to regulate neural crest migration.
By removing dopamine, the COMT enzyme helps regulate neural activity and maintain mental function.
Degenhardt, K. R. et al. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expression.
