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Since the Mediator complex can directly bind to Pol II (Naar et al. 1999; Casamassimi and Napoli 2007; Taatjes 2010; Soutourina et al. 2011; Lariviere et al. 2012), collectively it may regulate many genes.
A transcription factor in upstream of a pathway may regulate many target genes.
3– 6 It has been reported that TAZ may regulate many biological processes, including cell proliferation, migration, and invasion.
Second, the large number of variable miRNAs carried by exosomes may regulate many different signaling pathways, and will generate integral effects on recipient cells.
Recent data also suggest that, as well as activating angiogenesis, hypoxia may regulate many other features that are important in RA, such as cell trafficking and matrix degradation.
Since most of these receptors are abundantly expressed in the liver, the endogenous RA may regulate many hepatic nuclear receptor-mediated pathways.
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These changes in primary metabolism may further regulate many structural and transcriptional regulators.
Saying that I have misunderstood its conclusion, the majority maintains that the F.D.A. may clearly regulate many dangerous products without banning them.
Our results demonstrate the broad role of BACE1 activity in membrane protein turnover, and suggest that this protease may help regulate many diverse biological processes.
Given that NFκB is a master regulator in the immune system [ 23, 71, 77], RhoGTPases may, through NFκB, regulate many aspects of immunity, in particular innate immunity.
Moreover, bioinformatic analyses estimate that miRNAs may regulate as many as 30% of the human protein coding genes, suggesting that these small RNAs may act to coordinate the interplay between complex signal transduction pathways [ 19].
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