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These results raise the possibility that COX-2 may regulate intercellular signalling by both PG-dependent and PG-independent actions.
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For example, further research may provide insight into whether non-neuronal cell types regulate intercellular tau transfer, since glia are able to internalize tau aggregates in a mouse model of tauopathy [ 47] and glial tangles are also found in frontotemporal dementia [ 64].
Conversely, diatom-derived unsaturated aldehydes can regulate intercellular signalling, stress surveillance, and defence against grazers [ 41- 43].
We observed transcriptional changes consistent with these processes and the extensive intercellular signaling pathways that may regulate morphogenetic events during metamorphosis.
In a complex with Cx43, ZO-1, and SH3 i, Mena (and VASP) may regulate cytoplasmic networks and thereby stabilize the assembly and intercellular communication of gap junctions.
Phytophagous insects may regulate primary production.
RA may regulate neurogenesis via several mechanisms.
Alternatively, FruM may regulate dopamine neuronal activities.
Different oncogenic pathways may regulate common genes.
MALAT1 may regulate alternative splicing.
Other cytoskeletal elements (e.g., other microtubule-associated proteins, actin and myosin) may also be part of the machinery regulating intercellular trafficking [ 67, 68].
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