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The above data suggest that Cdc42 may regulate endocytosis.
36 Because varying factors may regulate endocytosis, the retrieval of SV membranes occurs at different rates.
For example, while several papers dispute the endocytic role of Atg6 [ 27, 30, 31], others suggest that Atg6 may regulate endocytosis and other processes as well [ 32, 34].
Alternatively, Rho GTPases may regulate endocytosis of desmosomal cadherins similar to their role in E-cadherin turnover (Akhtar and Hotchin 2001; Izumi et al. 2004; Kamei et al. 1999).
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Thus, these data show that Lpd, Mena, and F-actin contribute specifically to CME of the EGFR, suggesting that Lpd may regulate EGFR endocytosis via Mena and F-actin.
For example, the ability of ubiquitination to regulate endocytosis and endosomal membrane transport [29] may contribute to the maturation and budding of retroviruses [30], [31] and paramyxoviruses [32], including Rhabdoviruses, such as VSV and rabies virus [32], [33].
PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors.
ARF6 GTPase was shown to regulate endocytosis at several levels [15].
Sh3gl3 is an intracellular protein whose homologs have been suggested to regulate endocytosis and intracellular membrane trafficking [62].
To explore the endocytosis pathway further, we checked whether small GTPases and other related proteins known to regulate endocytosis might also be affected.
In our studies, MiTMAB blocked somal translocation in vitro but not leading process dynamics, suggesting that alternative forms of endocytosis may regulate adhesion at the growth cone vs. cell soma.
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