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NASP, an H1 histone binding protein, may regulate early events of spermatogenesis [42].
Our results demonstrate that human ES cell differentiation is accompanied by changes in the expression of a unique set of miRNAs, providing a glimpse of a new molecular circuitry that may regulate early development in humans.
The effects that we observed occurred shortly after NPC expansion suggesting that Cx36 may regulate early neurogenesis during development, perhaps to fine tune the establishment of neural networks within the brain.
Additionally, estrogens may regulate early signaling events, suggesting that the biological effects of environmental estrogens may not be mediated through classic ER (alpha and ss) activity alone.
Although little is currently known regarding the function of miR-489, a recent report indicated that miR-489 may regulate early osteogenic differentiation in human mesenchymal stem cells, and that miR-489 has critical roles in osteogenesis (Schoolmeesters et al, 2009).
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Based on our findings, anthocyanidin synthase may regulate earlier steps in the conversion of catechin, while the anthocyanidin reductase and leucoanthocyanidin reductase genes may both play important roles in the biosynthesis of galloylated catechins.
Another possibility is that PdeH may regulate the early stages of appressorium penetration, such as development of the penetration peg or differentiation of infectious hyphae.
Seven Type II genes exhibited significant expression changes in the two weeks following the short-day transition, indicating that these genes may regulate the earliest stages of growth cessation, terminal bud set and endodormancy establishment.
Moreover, DCC and IN α6 β4 are required in lipid rafts for Ntn-1 function, and may initiate various anti-apoptotic signaling transduction, and regulate early embryonic development.
Estradiol may also up-regulate early phase pro-inflammatory cytokines such as IL-1β and TNF-α and down-regulate anti-inflammatory cytokines such as IL-10 [ 53].
In conclusion, serotonin may regulate attentional modulation of early cortical stimulus processing.
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