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PIAS proteins may regulate distribution and activity of NK-like homeodomain proteins via SUMOylation as recently described for MSX1 and NKX2-5 [ 63, 64].
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Most astrocyte chemokine receptors are expressed in both primates and rodents, but species differences may regulate receptor distribution for some chemokine receptors.
Thus MAGUKs may regulate the distribution and also the function of transmembrane receptors and channels.
We also addressed the possibility that Rac1 peptide may regulate the distribution or differentiation of distinct T-cell subsets during the onset of CIA.
These results suggest that Ndel1 may regulate GluR1 intracellular distribution through Dyn2 GTPase activity.
Considering that Dyn2 regulates intracellular trafficking [31], [32] and endocytosis of the AMPA receptor subunit GluR1 [46], [46], we propose that Ndel1 may regulate GluR1 intracellular distribution in a similar way to Dyn2.
Phosphorylation of residues in the vicinity of the NES and NLS may regulate the intracellular distribution of a protein [ 6].
On the other hand, little is known concerning the expression and function of influx transporters that may regulate the brain distribution of drugs, except for relatively abundant expression of SLCO2A1 (OatP2A1) athehe mRNA level [ 8].
With the exception of prion diseases, this cell to cell transmission appears not to be infectious, at least for AD, PD and FTLD-Tau [ 63], but rather may regulate the spatial distribution and spread of pathology.
This has led to suggestions that the levels of podocalyxin expression may regulate adhesion by influencing the distribution and activities of other adhesion molecules on the cell surface [30].
Future studies may distinguish direct from indirect roles; for instance, these pathways may regulate gene expression and/or protein distributions of other genes within the ectoderm required to instruct mesoderm migration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com