Sentence examples for may regulate distinct from inspiring English sources

Thus, Hh and Wnt may regulate distinct pools of GSK3 and CK1 to achieve pathway specificity.

These data suggested that the agonistic and antagonistic miRNAs, while both potentially oncogenic, may regulate distinct sets of genes associated with different tumorigenic pathways.

Furthermore, it appears that β1-integrins are connected to differential signalling pathways in T-cells and may regulate distinct T-cell functions.

In a physiological setting, these results suggest that the PR-A and PR-B isoforms may regulate distinct sets of target genes and may exhibit different transactivational capabilities in a given progesterone-responsive target tissue.

Although ERα and ERβ share similar mechanisms of action, several differences in the transcriptional abilities of each receptor, as well as distinct phenotypes between gene-null animals, have been identified and suggest that these receptors may regulate distinct cellular pathways (Couse and Korach 1999; Curtis et al. 1996).

It is also possible that gt PREs may independently regulate distinct enhancers or may somehow cooperate in the establishment and/or maintenance of PcG-mediated repression.

Additionally, clustered miRNAs tend to regulate proteins that directly interact and that are part of the same network module (Yuan et al. 2009; Wang et al. 2011), but may also regulate distinct components of genetic pathways (Friggi-Grelin et al. 2008).

In this regard, although Brn-3a inhibits p53-mediated apoptic genes, it may cooperate with p53 to regulate distinct target genes that promote survival of specific cell populations that might affect long-term outcome in the injured heart.

Accordingly, differences exist between the transactivation domains of HIF isoforms [5], implying HIF-1α and HIF-2α may require different transcriptional cofactors to regulate distinct target genes.

Pramila et al. (2002 ) noted that the two factors' functions seem redundant as far as regulating known early cell-cycle target genes, and that they may interact with other cofactors to regulate distinct sets of genes.

Thus, activation of P2X7R may also activate different intracellular signaling mechanisms to regulate distinct cellular functions in various types of cells.