Although, Tau-induced morphological rescue of presynaptic terminals was almost equivalent to the values obtained with the expression of the endogenous TBPH protein itself (Figure 4F G and Figure 5B) functional recovery of larval motility was not achieved in Tau-rescued flies (Figure S4C) indicating that besides the stabilization of MTs, TBPH may regulates additional functions in motoneurons.
These data suggested that the 19S proteasome may play a role in regulating multienzyme recruitment to cytokine-inducible promoters, but does not eliminate the possibility that 19S ATPases may regulate an additional upstream event that is a prerequisite for these events.
Therefore, the gene expression array data set was interrogated to identify differentially expressed factors which may regulate transcription [see Additional file 19].
This suggests that PKA may regulate Gli2 ciliary localization through additional target sites on Gli2 or indirectly through the phosphorylation of other proteins.
Interestingly, the drop in blood pressure was more severe in SM-Dicer KO mice compared to previously reported data on miR-143/145 KO mice, suggesting that additional miRNAs may regulate VSMC functions.
We speculate, therefore, that additional mechanisms may regulate the activities of these proteins, and these mechanisms may differ between tissues.
It is of interest that tophus formation is not consistently present in all patients with long-standing hyperuricemia and gout, suggesting that additional factors may regulate the development of these lesions.
In view of that, it was described that rapid mitochondrial depolarization with ATP loss did not induce mitochondrial degradation by autophagy, implying that additional mechanisms may regulate mitophagy in neurons (51).
Despite these important discoveries, additional alleles that may regulate aging in humans and allow a minority of the population to attain extreme old age have likely yet to be identified.
