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The findings may reflect wider issues around the merits of discussing early stage CKD with patients who are often elderly and multimorbid, with concerns of unnecessary 'disease labelling' [ 2, 16, 17, 19, 32].
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We speculate that the relatively sparse cortical correlates shown in the voxel-based morphometry analysis of the C9ORF72 mutation cohort here may reflect wide inter-subject variation in cortical loss, with the more consistent involvement of subcortical grey matter structures (including thalamus and cerebellum) being a more robust signature of this mutation.
All statements are expert opinion and therefore constitute level 5 evidence and may not reflect wider clinical consensus.
This may reflect a wider shift in official reserves away from the benighted euro towards less troubled currencies.
That in turn may reflect a wider desire for a change of direction in the province.Mr Klein took office in 1992 with a simple mission: to restore Alberta to prosperity by cutting government spending and eliminating whopping deficits and debts.
On Tuesday, Music Week published a response piece where the magazine's editor Mark Sutherland argued that "The lack of diversity on the list may reflect a wider lack of diversity in the industry itself".
This may reflect a wider cultural issue of 'normalised deviance', where frequent errors are perceived as unsurprising or even acceptable.
Rather than reflecting previously untreated chronic pain, these patterns may reflect a wider change in the general approach to prescribing for pain [ 5, 16].
These responses may reflect a wider perception of LBP as attracting largely negative stereotypes of sufferers, and which potentially detract from a person-orientated approach to management.
The overall decline in well-being across the study in both groups may reflect the wider changes in the NHS of continuing reorganisation, recession, declining resources and job insecurity.
This extended to a lack of strategic planning for HRH to meet current and future needs, and may reflect a wider lack of attention to the HRH strategy development process [ 43].
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